Salix babylonica: uma fonte de compostos ativos para o tratamento de doenças inflamatórias em animais
Palavras-chave:
Salix babylonica, efeito anti-inflamatório, neutrófilosResumo
O bem-estar dos animais terrestres descreve as expectativas da sociedade em relação às condições que
os animais devem experimentar quando estão sob controle humano. Esses princípios incluem que os
animais devem estar livres de dor, lesões e doenças. A inflamação é um mecanismo de defesa do
hospedeiro contra infecções bacterianas ou virais, ou lesões físicas ou químicas no hospedeiro. Os
metabólitos secundários de plantas são uma alternativa eficaz para o tratamento de doenças inflamatórias.
O objetivo desta pesquisa foi avaliar a capacidade anti-inflamatória de um extrato hidroalcoólico de folhas
de Salix babylonica (HESB) usando o modelo de edema atrial induzido por TPA em camundongos. O HESB
apresentou boa atividade anti-inflamatória sem diferença estatística significativa com o medicamento de
referência, a indometacina. Por esse motivo, foi realizada uma bipartição do HESB, obtendo-se uma fração
aquosa (AFSB) com atividade farmacológica leve (30,64 ± 3,03 %) e uma fração orgânica (EAFSB) que
apresentou o melhor efeito anti-inflamatório (67,08 ± 7,15 %). Anteriormente, identificamos os flavonoides
anti-inflamatórios luteolina e luteolosídeo como os principais componentes da EAFSB, de modo que o efeito
anti-inflamatório da Salix babylonica pode ser atribuído a esses compostos. Além disso, a análise
histopatológica mostrou que as orelhas de camundongos tratados com Salix babylonica suprimiram a
infiltração de neutrófilos no local da inflamação. Esses resultados apoiam o uso etnomédico dessa planta
e fornecem evidências para o possível uso da Salix babylonica no tratamento do processo inflamatório em
animais.
e2021-32
http://dx.doi.org/10.21929/abavet2023.9
https://www.youtube.com/watch?v=dJBhroMsr9E
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