Efecto antibacteriano del extracto metanólico de Salix babylonica sobre bacterias de importancia en salud pública

Autores

  • Eddy González-Alamilla

Palavras-chave:

Salix babylonica

Resumo

O uso excessivo de antimicrobianos tem gerado resistência dos microrganismos a estes, têm sido buscadas alternativas eficazes no tratamento de doenças causadas por microrganismos resistentes ou multirresistentes a antibióticos, dentre essas alternativas estão as plantas, que devido ao seu conteúdo composto de efeitos colaterais têm atividade antibacteriana. O objetivo do presente estudo foi caracterizar e determinar a atividade antibacteriana do extrato metanólico de Salix babylonica (SB) em bactérias de importância para a saúde pública. Para obtenção do extrato, foi utilizada a técnica de maceração, caracterização química qualitativa e quantitativa por cromatografia gasosa. Para determinar a atividade antibacteriana, foram determinadas a Concentração Inibitória Mínima (CIM) e a Concentração Bactericida Mínima (CBM) e a caracterização do extrato permitiu a identificação de compostos fenólicos, cumarinas, lactonas, flavonóis, quinonas, saponinas, triterpenos e compostos esteróides, além de compostos fenólicos. Timol (0,5319 mg/ml) e Carvacrol (0,4158 mg/ml). Com relação à atividade antibacteriana, a melhor atividade foi apresentada contra o Bacillus subtillis (CIM: 12,5 mg/mL e CBM: 25 mg/mL), Listeria monocytogenes e Staphylococcus aureus (CIM: 25 mg/mL e CBM: 50 mg/mL). Conclui-se que o extrato metanólico de SB pode ser uma alternativa para o tratamento de doenças causadas por bactérias
resistentes a antibióticos ou multiresistentes.

Referências

ALÓS JI. 2014. Resistencia bacteriana a los antibóticos: una crisis global. Enfermedades Infecciosas y Microbiologias Clinica. 33(10):692–699. http://dx.doi.org/10.1016/j.eimc.2014.10.004

BALOUIRI M, Sadiki M, Ibnsouda SK. 2016. Methods for in vitro evaluating antimicrobial activity: A review. Journal of Pharmaceutical Analysis. 6(2):71-79. https://doi.org/10.1016/j.jpha.2015.11.005.

BAÑUELOS-VALENZUELA R, Delgadillo L, Chairez F, Delgadillo O, Meza-López C. 2018. Composición química y FTIR de extractos etanólicos de Larrea tridentata, Origanum vulgare, Artemisa ludoviciana y Ruta graveolens Agrociencia. 52(3): 309-321. https://dialnet.unirioja.es/servlet/articulo?codigo=6423180.

BERRIDGE MV, Herst PM, Tan AS. 2005. Tetrazolium dyes as tools in cell biology: new insights into their cellular reduction. Biotechnology Annual Review. 11:127-152. https://doi.org/10.1016/s1387-2656(05)11004-7.

BORGES A, Ferreira C, Saavedra MJ, Simoes, M. 2013. Antibacterial activity and mode of action of ferulic and gallic acids against pathogenic bacteria. Microbial Drug Resistance. 19(4): 256-265. https://doi.org/10.1089/mdr.2012.0244.

CLSI (Clinical and Laboratory Standards Institute). 2012. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically; Approved Standard-Ninth Edition. Pp. 88. USA.

HERNÁNDEZ-ALVARADO J, Zaragoza-Bastida A, López-Rodríguez G, Peláez-Acero A, Olmedo-Juárez A, Rivero-Perez N. 2018. Actividad antibacteriana y sobre nematodos gastrointestinales de metabolitos secundarios vegetales: enfoque en Medicina Veterinaria. Abanico Veterinario. 8(1):14-27. http://dx.doi.org/10.21929/abavet2018.81.1.

KAEWPIBOON C, Lirdprapamongkol K, Srisomsap C, Winayanuwattikun P, Yongvanich T, Puwaprisirisan P, Svasti J, Assavalapsakul W. 2012. Studies of the in vitro cytotoxic, antioxidant, lipase inhibitory and antimicrobial activities of selected Thai medicinal plants. BMC Complementary and Alternative Medicine. 12(1):217. https://doi.org/10.1186/1472-6882-12-217.

KAYE KS, Engemann JJ, Fraimow HS, Abrutyn E. 2004. Pathogens resistant to antimicrobial agents: epidemiology, molecular mechanisms, and clinical management. Infectious disease clinics of North America. 18(3):467-511. https://doi.org/10.1016/j.idc.2004.04.003.

KHAN UA, Rahman H, Niaz Z, Qasim M, Khan J, Tayyaba, Rehman B. 2013. Antibacterial activity of some medicinal plants against selected human pathogenic bacteria. European Journal of Microbiology and Immunology. 3(4): 272–274. https://doi.org/10.1556/EuJMI.3.2013.4.6

LOZANO R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, et al., 2012.Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. 2012. The Lancet. 380(9859):2095-2128. https://doi.org/10.1016/S0140-6736(12)61728-0

MAGI G, Marini E, Facinelli B. 2015. Antimicrobial activity of essential oils and carvacrol, and synergy of carvacrol and erythromycin, against clinical, erythromycin-resistant Group A Streptococci. Frontiers in Microbiology. 6:165. https://doi.org/10.3389/fmicb.2015.00165.

MOTHANA RA, Lindequist U, Gruenert R, Bednarski PJ. 2009. Studies of the in vitro anticancer, antimicrobial and antioxidant potentials of selected Yemeni medicinal plants from the island Soqotra. BMC Complementary and Alternative Medicine. 9: 7. https://doi.org/10.1186/1472-6882-9-7.

NDHLALA AR, Ghebrehiwot HM, Ncube B, Aremu AOJ, Gruz M, Subrtova J, Van Staden A. 2015. Antimicrobial, anthelmintic activities and characterization of functional phenolic acids of Achyranthes aspera linn, a medicinal plant used for the treatment of wounds and ringworm in east Africa. Frontiers in Pharmacology. 6:274. https://doi.org/10.3389/fphar.2015.00274.

RENISHEYA JJMT, Johnson M, Mary UM, Arthy A. 2011. Antibacterial activity of ethanolic extracts of selected medicinal plants against human pathogens. Asian Pacific Journal of Tropical Biomedicine.1(1):S76-S78. https://doi.org/10.1016/S2221-1691(11)60128-7.

RIVERO-PEREZ N, Ayala-Martínez M, Zepeda-Bastida A, Meneses-Mayo M, Ojeda-Ramírez D. 2016. Anti-inflammatory effect of aqueous extracts of spent Pleurotus ostreatus substrates in mouse ears treated with 12-O-tetradecanoylphorbol-13-acetate. Indian Journal of Pharmacology. 48(2):141-144. https://dx.doi.org/10.4103%2F0253-7613.178826.

SALEM AFZ, Salem MZ, González-Ronquillo M, Camacho LM, Cipriano M. 2011. Major chemical constituents of Leucaena leucocephala and Salix babylonica leaf extracts. Journal of Tropical Agriculture. 49: 95-98. http://jtropag.kau.in/index.php/ojs2/article/view/244

SULAIMAN GM, Hussien NN, Marzoog TR, Awad, HA. 2013. Phenolic content, antioxidant, antimicrobial and cytotoxic activities of ethanolic extract of Salix alba. American Journal of Biochemistry and Biotechnology. 9(1): 41-46. https://thescipub.com/PDF/ajbbsp.2013.41.46.pdf.

WAHAB GA, Sallam A, Elgaml A, Lahhloub M, Afifi MS. 2018. Antioxidant and antimicrobial activities of Salix babylonica extracts. World Journal of Pharmaceutical Sciences. 6(4): 1-6. http://www.wjpsonline.org/.

WHO (World Health Organization). 2017. Antimicrobial resistance. https://www.who.int/antimicrobial-resistance/en/

WIEGAND I, Hilpert K, Hancock REW. 2008. Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances. Nature Protocols. 3(2):163-175. https://doi.org/10.1038/nprot.2007.521.

Publicado

2020-01-06

Edição

Seção

Artigos Originais

Artigos Semelhantes

Você também pode iniciar uma pesquisa avançada por similaridade para este artigo.