Supervivencia de Pasteurella multocida aislada de conejo a la lisis inducida por el sistema complemento
Palabras clave:
Pasteurelosis, inhibición del desarrollo, bacteria, complejo de ataque a la membranaResumen
La pasteurelosis es una enfermedad bacteriana que provoca daños económicos en sistemas de producción cunícola de todo el mundo y es una zoonosis comprobada en humanos infectados por los animales de compañía. El sistema complemento causa la lisis de diversos microorganismos patógenos formando el complejo de ataque a la membrana. El objetivo del presente trabajo fue evaluar la actividad del complemento sérico humano sobre la capacidad de supervivencia de un aislado virulento de Pasteurella multocida tipo A. La bacteria se obtuvo de un caso clínico de una coneja con neumonía, por medio de un hisopado nasal para aislamiento en cultivo puro e identificación por pruebas bioquímicas. P. multocida fue enfrentada por 30 min a 37°C, a suero humano normal y a suero humano inactivado por calor. La lisis por la acción del complemento tuvo una reducción significativa en la viabilidad del microorganismo comparado con el cultivo enfrentado al complemento inactivado (P< 0.05), sin embargo, el 51.07 ± 1.70 % logró evadir la actividad lítica del complemento. En la presente investigación se concluye que el sistema complemento ofrece protección parcial contra infecciones por P. multocida serotipo A causante de pasteurelosis neumónica en conejos.
http://dx.doi.org/10.21929/abavet2022.231
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