Amiloidosis sistémica AA: un problema potencial de salud pública
Palabras clave:
Salud pública, inocuidad alimentaria, amiloidosis, inflamación crónica, insuficiencia renalResumen
El objetivo de esta revisión es informar a los profesionales en salud animal, sobre la amiloidosis sistémica AA, un problema potencial de salud pública poco conocido en México, que puede derivarse del consumo de productos animales. Es difícil de diagnosticar, pues los signos clínicos dependen del tipo y localización del amiloide; y su fase terminal corresponde con un cuadro de insuficiencia renal. Consiste en la acumulación de un material proteico extracelular que puede originarse a partir de alrededor de 37 proteínas normales en los humanos y más de 15 en otros mamíferos acuáticos y terrestres, y en aves. Posee una estructura fibrilar característica en disposición β plegada que le confiere gran resistencia a agentes fisicoquímicos, que hace difícil su eliminación de los alimentos. Algunas amiloidosis, como el Alzheimer en humanos y el trastorno de disfunción cognitiva en los perros, son localizadas, pero la amiloidosis AA es sistémica y existe evidencia natural y experimental de que puede transmitirse intra e inter-especie cuando hay ingreso por vía oral, intravenosa o intraperitoneal de material amiloide en un individuo con una enfermedad inflamatoria crónica pre-existente u otros factores de riesgo, como la obesidad, lo que la convierte en un potencial problema de salud pública.
http://dx.doi.org/10.21929/abavet2022.11 e2021-22.
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