Estrés por calor: influencia sobre la fisiología, comportamiento productivo y reproductivo del cerdo

Autores/as

Palabras clave:

cerdo, estrés por calor, desempeño reproductivo, desempeño productivo

Resumen

El estrés por calor (EC) compromete parámetros reproductivos y de crecimiento. Los cerdos sometidos a estrés por calor reducen el consumo voluntario y modifican su metabolismo energético provocando la reducción en la ganancia diaria de peso y un incremento en la acumulación de grasa subcutánea, que afecta de manera negativa la calidad de la canal de los cerdos de engorda. En la cerda provoca un balance energético negativo afectando su desempeño reproductivo al incrementar el intervalo celo posdestete, disminuir la tasa de gestación, tasa de partos y tamaño y peso de la camada al nacimiento y al destete. Muchas de las consecuencias negativas del EC parecen estar mediadas por la hiperpermeabilidad de la barrera intestinal, provocando cambios fisiológicos como el reparto de nutrientes hacia un sistema inmunológico activado y efectos adversos en los ovarios a través de la señalización elevada de endotoxinas e insulina, que resultan en fallas en la función reproductiva de la cerda.

http://dx.doi.org/10.21929/abavet2022.37                      

 e2022-22

https://www.youtube.com/watch?v=HHSio8kwjAg

 

Citas

ABRAHAM SM, Lawrence T, Kleiman A, Warden P, Medghalchi M, Tuckermann J, Saklatvala J, Clark AR. 2006. Anti-inflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1. Journal of Experimental Medicine. 203(8):1883-1889. ISSN: 1540-9538. https://doi.org/10.1084/jem.20060336

AGRAWAL V, Jaiswal MK, Jaiswal YK. 2013. Lipopolysaccharide-induced modulation in the expression of progesterone receptor and estradiol receptor leads to early pregnancy loss in mouse. Zigote. 21(4):337-344. ISSN: 1469-8730.

https://doi.org/10.1017/S0967199412000330

ALHENAKY A, Abdelqader A, Abuajamieh M, Al-Fataftah AR. 2017. The effect of heat stress on intestinal integrity and Salmonella invasion in broiler birds. Journal of Thermal Biology. 70(Part B):9-14. ISSN: 0306-4565. https://doi.org/10.1016/j.jtherbio.2017.10.015

BAUMGARD LH, Rhoads RP. 2013. Effects of heat stress on postabsorptive metabolism and energetics. Annual Review of Animal Bioscience. 1:311-337. ISSN‎: ‎2165-8102. https://doi.org/10.1146/annurev-animal-031412-103644

BECKER L, Schade U, Rohleder N. 2020. Activation of the hypothalamic-pituitary adrenal axis in response to a verbal fluency task and associations with task performance. PLoS One.15(4): e0227721. ISSN 1932-620. https://doi.org/10.1371/journal.pone.0227721.

BIDNE KL, Dickson MJ, Ross JW, Baumgard LH, Keating AF. 2018. Disruption of female reproductive function by endotoxins. Reproduction and fertility. 155(4): R169–R181. ISSN 1741–7899. https://doi.org/10.1530/REP-17-0406

BODDICKER RL, Seibert JT, Johnson JS, Pearce SC, Selsby JT, Gabler NK, Lucy MC, Safranski TJ, Rhoads RP, Baumgard LH, Ross JW. 2014. Gestational heat stress alters postnatal offspring body composition indices and metabolic parameters in pigs. PLoS One. 9(11): e110859. ISSN: 1932-6203. https://doi.org/10.1371/journal.pone.0110859

BOTTO L, Lendelová J, Strmeňová A, Reichstädterová T. 2014. The effect of evaporative cooling on climatic parameters in a stable for sows. Research in Agricultural Engineering. 60(Special Issue): S85–S91. https://doi.org/10.17221/40/2013-RAE

BUNZ AMG, Bunter KL, Morrison RS, Luxford BG, Hermesch S. 2019. Differences in farrowing rate according to parity and trait specific temperature groupings around mating events. Advances in Animal Biosciences. Manipulating Pig Production XVII: Proceedings of the Fourteenth Biennial Conference of the Australasian Pig Science Association. 10 (suppl 1):9. ISSN 2040-4719. https://rune.une.edu.au/web/handle/1959.11/29083

CERVANTES M, Antoine D, Valle JA, Vásquez N, Camacho RL, Bernal H, Morales A. 2018. Effect of feed intake level on the body temperature of pigs exposed to heat stress conditions. Journal of Thermal Biology. 76: 1-7. ISSN 0306-4565. https://doi.org/10.1016/j.jtherbio.2018.06.010.

COLLIER RJ, Renquist BJ, Xiao Y. 2017. A 100-Year Review: Stress physiology including heat stress. Journal of Dairy Science. 100(12):10367-10380. ISSN: 0022-0302. https://doi.org/10.3168/jds.2017-13676

CROSS AJ, Brown-Brandl TM, Keel BN, Cassady JP, Rohrer GA. 2020. Feeding behavior of grow-finish swine and the impacts of heat stress.Translational Animal Science. 4(2): 986–992. ISNN 25732102. https://doi.org/10.1093/tas/txaa023

CRUZEN S, Boddicker R, Graves K, Johnson T, Arkfeld E, Baumgard L, Ross J, Safranski T, Lucy M, Lonergan S. 2015. Effects of long-term heat stress in utero or during finishing on pork carcass composition. Meat Science. 101:108-118. ISSN: 0309-1740. http://doi.org/10.1016/j.meatsci.2014.09.026

CUI Y, Gu X. 2015. Proteomic changes of the porcine small intestine in response to chronic heat stress. Journal of Molecular Endocrinology. 55(3):277-293. ISSN: 1479-6813. https://doi.org/10.1530/JME-15-0161

CUI Y, Hao Y, Li J, Bao W, Li G, Gao Y, Gu X. 2016. Chronic Heat Stress Induces Immune Response, Oxidative Stress Response, and Apoptosis of Finishing Pig Liver: A Proteomic Approach. International Journal of Molecular Science. 17(5):393-416. ISSN 1422-0067. https://doi.org/10.3390/ijms17050393

DE RENSIS F, Ziecik AJ, Kirkwood RN. 2017. Seasonal infertility in gilts and sows: Aetiology, clinical implications and treatments.Theriogenology. 96: 111-117. ISSN 0093-691X. https://doi.org/10.1016/j.theriogenology.2017.04.004.

DENG W, Dong XF, Tong JM, Zhang Q. 2012. The probiotic Bacillus licheniformis ameliorates heat stress induced impairment of egg production, gut morphology, and intestinal mucosal immunity in laying hens. Poultry Science. 91(3):575-582. ISSN: 1349-0486. https://doi.org/10.3382/ps.2010-01293

DICKSON MJ, Hager CL, Al-Shaibi A, Thomas PQ, Baumgard LH, Ross JW, Keating AF. 2018. Impact of heat stress during the follicular phase on porcine ovarian steroidogenic and phosphatidylinositol-3 signaling. Journal of Animal Science. 96(6):2162-2174. ISSN: 1525-3163. https://doi.org/10.1093/jas/sky144

FONSECA SF, Teles MC, V. Ribeiro GC, Magalhaes FC, Mendonça VA, Peixoto MFD, Leite LHR, Coimbra CC, Lacerda ACR. 2015. Hypertension is associated with greater heat Exchange during exercise recovery in a hot environment. Brazilian Journal of Medical and Biological Research. 48(12):1122-1129. ISSN: 1414-431X.

https://doi.org/10.1590/1414-431X20154532

GABLER NK, Koltes D, Schaumberger S, Murugesan GR, Reisinger N. 2018. Diurnal heat stress reduces pig intestinal integrity and increases endotoxin translocation. Translational Animal Science. 2(1):1-10. ISSN: 2573-2002. https://doi.org/10.1093/tas/txx003

GANESAN S, Summers CM, Pearce SC, Gabler NK, Valentine RJ, Baumgard LH, Rhoads RP, Selsby JT. 2017. Short-term heat stress causes altered intracellular signaling in oxidative skeletal muscle. Journal of Animal Science, 95(6):2438-2451. ISSN: 1525-3163. https://doi.org/10.2527/jas.2016.1233

GAO CQ, Zhao YL, Li HC, Sui WG, Yan HC, Wang XQ. 2015. Heat stress inhibits proliferation, promotes growth, and induces apoptosis in cultured Lantang swine skeletal muscle satellite cells. Journal Zhejiang University-Science B (Biomedicine & Biotechnology), 16(6):549-559. ISSN: 1862-1783. https://doi.org/10.1631/jzus.B1400339

GORDON BS, Kelleher AR, Kimball SR. 2013. Regulation of muscle protein synthesis and the effects of catabolic states. The International Journal of Biochemistry & Cell Biology. 45(10):2147-57. ISSN: 1357-2725. https://doi.org/10.1016/j.biocel.2013.05.039

GOURDINE JL, Rauw WM, Gilbert H, Poullet N. 2021. The Genetics of Thermoregulation in Pigs: A Review. Frontiers in Veterinary Science. 13(8):770480. ISSN: 2297-1769. https://doi.org/10.3389/fvets.2021.770480

HAO Y, Feng Y, Yang P, Feng J, Lin H, Gu X. 2014. Nutritional and physiological responses of finishing pigs exposed to a permanent heat exposure during three weeks. Archives of Animal Nutrition. 68(4):296-308. ISSN‎: ‎1745-039X.

https://doi.org/10.1080/1745039X.2014.931522

HERMAN JP, McKlveen JM, Ghosal S, Kopp B, Wulsin A, Makinson R, Scheimann J, Myers B. 2016. Regulation of the Hypothalamic-Pituitary-Adrenocortical Stress Response. Compr Physiol. 6(2):603-621. ISSN: 2040-4603.

https://doi.org/10.1002/cphy.c150015

INBARAJ S, Sejian V, Bagath M, Bhatta R. 2016. Impact of Heat Stress on Immune Responses of Livestock: A Review. Pertanika Journal Tropical Agricultural Science. 39(4):459-482. ISSN: 1511-3701.

http://www.pertanika.upm.edu.my/resources/files/Pertanika%20PAPERS/JTAS%20Vol.%2039%20(4)%20Nov.%202016/03%20JTAS%200809-2015%20-%20Review%20Article.pdf

ISERI VJ, Klasing KC. 2013. Dynamics of the systemic components of the chicken (Gallus domesticus) immune system following activation by Escherichia coli; implications for the costs of immunity. Developmental & Comparative Immunology. 40(3-4):248-257. ISSN: 0145-305x. https://doi.org/10.1016/j.dci.2013.02.005

JANKORD R, Zhang R, Flak JN, Solomon MB, Albertz J, Herman JP. 2010. Stress activation of IL-6 neurons in the hypothalamus. The American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 299: R343–351. ISSN: 15221490. https://doi.org/10.1152/ajpregu.00131.2010

JOHNSON JS, Boddicker RL, Sanz-Fernandez MV, Ross JW, Selsby JT, Lucy MC, Safransky TJ, Rhoads RP, Baumgard RP. 2013. Effects of mammalian in utero heats tress on adolescent body temperature. International Journal of Hyperthermia. 29(7):696-702. ISSN: 1464-5157. https://doi.org/10.3109/02656736.2013.843723

JOHNSON JS, Sanz Fernandez MV, Gutierrez NA, Patience JF, Ross JW, Gabler NK, Lucy MC, Safranski TJ, Rhoads RP, Baumgard LH. 2015a. Effects of in utero heat stress on postnatal body composition in pigs: I. Growing phase. Journal of Animal Science. 93(1):71-81. ISSN: 1525-3163. https://doi.org/10.2527/jas.2014-8354

JOHNSON JS, Sanz Fernandez MV, Patience JF, Ross JW, Gabler NK, Lucy MC, Safranski TJ, Rhoads RP, Baumgard LH. 2015b. Effects of in utero heat stress on postnatal body composition in pigs: II. Finishing phase, Journal of Animal Science. 93(1): 82–92. https://doi.org/10.2527/jas.2014-8355

JOHNSON JS, Sapkota A, Lay DC Jr. 2016. Rapid cooling after acute hyperthermia alters intestinal morphology and increases the systemic inflammatory response in pigs. Journal of Applied Physiology. 120(10):1249-1259. ISSN: 1522-1601.

https://doi.org/10.1152/japplphysiol.00685.2015

JOSEPH DN, Whirledge S. 2017. Stress and the HPA Axis: Balancing Homeostasis and Fertility. International Journal of Molecular Science. 18(10): 2224. ISSN 1422-0067 https://doi.org/10.3390/ijms18102224

KEY N, Sneeringer S, Marquardt D. 2014. Climate change, heat stress, and U.S. dairy production. United States Department of Agriculture. Report ERR175:1-45. http://dx.doi.org/10.2139/ssrn.2506668

KVIDERA SK, Horst EA, Mayorga EJ, Sanz-Fernandez MV, Abuajamieh M, Baumgard LH. 2017. Estimating glucose requirements of an activated immune system in growing pigs. Journal of Animal Science. 95(11):5020-5029. ISSN: 1525-3163. https://doi.org/10.2527/jas2017.1830

LIU F, de Ruyter EM, Athorn RZ, Brewster CJ, Henman DJ, Morrison RS, Smits RJ, Cottrell JJ, Dunshea FR. 2019. Effects of L-citrulline supplementation on heat stress physiology, lactation performance and subsequent reproductive performance of sows in summer. Journal of Animal Physiology and Animal Nutrition. 103: 251– 257. ISSN:1439-0396. https://doi.org/10.1111/jpn.13028

LIU F, Zhao W, Le HH, Cottrell JJ, Green MP, Leury BJ, Dunshea FR, Bell AW. 2022. Review: What have we learned about the effects of heat stress on the pig industry? Animal. 16(2):100349. ISSN 1751-7311. https://doi.org/10.1016/j.animal.2021.100349

LIU X, Li H, Lu A, Zhong Y, Hou X, Wang N, Jia D, Zan J, Zhao H, Xu J, Liu F. 2012. Reduction of intestinal mucosal immune function in heat-stressed rats and bacterial translocation. International Journal of Hyperthermia. 28(8): 756-765. ISSN‎: ‎0265-6736. https://doi.org/10.3109/02656736.2012.729173

LOCKE M, Celotti C. 2014. The effect of heat stress on skeletal muscle contractile properties. Cell Stress and Chaperones. 19(4):519-527. ISSN: 1466-1268. https://doi.org/10.1007/s12192-013-0478-z

LUCY MC, Safraski TJ. 2017. Heat stress in pregnant sows: Thermal responses and subsequent performance of sows and their offspring. Molecular Reproduction and Development. 84(9):946-956. ISSN: 1098-2795. https://doi.org/10.1002/mrd.22844

MAKKER A, Goel MM, Mahdi AA. 2014. PI3K/PTEN/Akt and TSC/mTOR signaling pathways, ovarian dysfunction, and infertility: an update. Journal of Molecular Endocrinology. 53(3): R103-R118. ISSN: 1479-6813. https://doi.org/10.1530/JME-14-0220

MAYORGA EJ, Ross JW, Keating AF, Rhoads RP, Baumgard LH. 2020. Biology of heat stress; the nexus between intestinal hyperpermeability and swine reproduction. Theriogenology. 154:73-83. ISSN: 0093-691x.

https://doi.org/10.1016/j.theriogenology.2020.05.023

MERKS JWM, Mathur PK, Knol EF. 2012. New phenotypes for new breeding goals in pigs. Animal. 6:535–543. ISSN 1751-7311. https://doi.org/10.1017/S1751731111 002266

MORERA P, Basiricò L, Hosoda K, Bernabucci U. 2012. Chronic heat stress up-regulates leptin and adiponectin secretion and expression and improves leptin, adiponectin and insulin sensitivity in mice. Journal of Molecular Endocrinolog. 48(2):129-138. ISSN: 1479-6813. https://doi.org/10.1530/JME-11-0054

MYER R, Bucklin R. 2012. Influence of hot-humid environment on growth performance and reproduction of swine. University of Florida. AN107. Institute of Food and Agricultural Sciences Extension. Gainesville, FL. https://edis.ifas.ufl.edu/pdffiles/AN/AN10700.pdf

NTEEBA J, Sanz-Fernandez MV, Rhoads RP, Baumgard LH, Ross JW, Keating AF. 2015. Heat stress alters ovarian insulin-mediated phosphatidylinositol-3 kinase and steroidogenic signaling in gilt Ovaries. Biology of Reproduction. 92(6):148,1-8. ISSN: 0006-3363. https://doi.org/10.1095/biolreprod.114.126714

O’HEA EK, Leveille GA. 1969. Significance of adipose tissue and liver as sites of fatty acid synthesis in the pig and the efficiency of utilization of various substrates for lipogenesis. The Journal of Nutrition. 99(3):338-344. ISSN: 0022-3166, https://doi.org/10.1093/jn/99.3.338

OGDEN HB, Child RB, Fallowfield JL, Delves SK, Westwood CS, Layden JD. 2020. The gastrointestinal exertional heat stroke paradigm: pathophysiology, assessment, severity, aetiology and nutritional countermeasures. Nutrients. 12(2):537,1-42. ISSN: 2072-6643. https://doi.org/10.3390/nu12020537

PEARCE SC, Gabler NK, Ross JW, Escobar J, Patience JF, Rhoads RP, Baumgard L H. 2013a. The effects of heat stress and plane of nutrition on metabolism in growing pigs. Short-term exposure to heat stress attenuates appetite and intestinal integrity in growing pigs. Journal of Animal science. 91(5):2108-2118. ISSN: 1525-3163. https://doi.org/10.2527/jas.2012-5738

PEARCE SC, Mani V, Boddicker RL, Johnson JS., Weber TE, Ross JW, Rhoads RP, Baumgard LH, Gabler NK. 2013b. Heat stress reduces intestinal barrier integrity and favors intestinal glucose transport in growing pigs. PLoS ONE. 8(8): e70215. ISSN: 1932-6203, https://doi.org/10.1371/journal.pone.0070215

PEARCE SC, Sanz-Fernandez MV, Hollis JH, Baumgard LH, Gabler NK. 2014. Short-term exposure to heat stress attenuates appetite and intestinal integrity in growing pigs. Journal of Animal science. 92(12):5444-5454. ISSN: 1525-3163. https://doi.org/10.2527/jas.2014-8407

PLUSH K, Glencorse D, Alexopoulos J, Tritton S, Kirkwood R, D’Souza D. 2019. Effect of Dextrose Supplementation in the Pre-Ovulatory Sow Diet to Reduce Seasonal Influences on Litter Birth Weight Variation. Animals. 9(12):1009. ISSN 1751-7311. https://doi.org/10.3390/ani9121009

PREISER JC, Ichai C, Orban JC, Groeneveld ABJ. 2014. Metabolic response to the stress of critical illness. British Journal of Anaesthesia. 113 (6):945-954. ISSN 0007-0912. https://doi.org/10.1093/bja/aeu187

QI H, Wang P, Liu C, Li M, Wang S, Huang Y, Wang F. 2011. Involvement of HIF-1a in MLCK-dependent endothelial barrier dysfunction in hypoxia. Cellular Physiology and Biochemistry. 27(3-4):251-262. ISSN‎: ‎1421-9778, https://doi.org/10.1159/000327951

QU H, Yan H, Lu H, Donkin SS Ajuwon KM. 2016. Heat stress in pigs is accompanied by adipose tissue-specific responses that favor increased triglyceride storage. Journal of Animal Science. 94(5):1884-1896. ISSN 1525-3163. https://doi.org/10.2527/jas.2015-0084

RENAUDEAU D, Collin A, Yahav S, de Basilio V, Gourdine JL, Collier RJ. 2012. Adaptation to hot climate and strategies to alleviate heat stress in livestock production. Animal. 6(5):707-728. ISSN: 1751-732X. https://doi.org/10.1017/S1751731111002448

RENAUDEAU D, Frances G, Dubois S, Gilbert H, Noblet J. 2013. Effect of thermal heat stress on energy utilization in two lines of pigs divergently selected for residual feed intake. Journal of Animal Science. 91(3):1162-1175. ISSN: 1525-3163.

https://doi.org/10.2527/jas.2012-5689

RENAUDEAU D, Gourdine JL, St-Pierre NR. 2011. A meta-analysis of the effects of high ambient temperature on growth performance of growing finishing pigs. Journal of Animal Science. 89(7):2220-2230. ISSN: 1525-3163. https://doi.org/10.2527/jas.2010-3329

RINALDO D, Le Dividich J. 1991. Effects of warm exposure on adipose tissue and muscle metabolism in growing pigs. Comparative Biochemistry and Physiology Part A: Physiology. 100:995-1002. ISSN: 1095-6433. https://doi.org/10.1016/0300-9629(91)90327-9

ROSS JW, Hale BJ, Gabler NK, Rhoads RP, Keating AF, Baumgard LH. 2015. Physiological consequences of heat stress in pigs. Animal Production Science. 55(12):1381-1390. ISSN: 1836-0939. http://doi.org/10.1071/AN15267

SANDERS SR, Cole LC, Flann KL, Baumgard LH, Rhoads RP. 2009. Effects of acute heat stress on skeletal muscle gene expression associated with energy metabolism in rats. The FASEB Journal. 23(Suppl.1):598-597. ISSN: 1530-6860.

https://doi.org/10.1096/fasebj.23.1_supplement.598.7

SANZ-FERNÁNDEZ MV, Johnson JS, Abuajamieh M, Stoakes SK, Seibert JT, Cox L, Kahl S, Elsasser TH, Ross JW, Isom SC, Rhoads RP, Baumgard LH. 2015. Effects of heat stress on carbohydrate and lipid metabolism in growing pigs. Physiological Reports. 3(2): e12315. ISSN: 2051-817X. https://doi.org/10.14814/phy2.12315

SANZ-FERNÁNDEZ MV, Pearce SC, Gabler NK, Patience JF, Wilson ME, Socha MT, Torrison JL, Rhoads RP, Baumgard LH. 2014. Effects of supplemental zinc amino acid complex on gut integrity in heat-stressed growing pigs. Animal. 8(1):43–50. ISSN: 1751-732X. https://doi.org/10.1017/S1751731113001961

TUMANENG K, Russell RC, Guan KL. 2012. Organ size control by hippo and tor pathways. Current Biology. 22(9): R368-R379. ISSN: 0960-9822. https://doi.org/10.1016/j.cub.2012.03.003

VOLODINA O, Ganesan S, Pearce SC., Gabler NK, Baumgard LH, Rhoads RP, Selsby JT. 2017. Short-term heat stress alters redox balance in porcine skeletal muscle. Physiological Reports. 5(8): e13267. ISSN: 2051-817X.

https://doi.org/10.14814/phy2.13267

WEBSTER MJI, Glaser R. 2008. Review: Stress hormones and immune function. Cellular Immunology. 252(1-2):16-26. ISSN: 0008-8749.

https://doi.org/10.1016/j.cellimm.2007.09.006

WEGNER K, Lambertz C, Das G, Reiner G, Gauly M. 2016. Effects of temperature and temperature-humidity index on the reproductive performance of sows during summer months under a temperate climate. Animal Science Journal. 87(11):1334-1339. ISSN‎: ‎1740-0929. https://doi.org/10.1111/asj.12569

XIN W, Ze-yang L, An-feng J, Hong-guang S, Chun-hong H, Min-hong Z, Jing-hai F. 2016. Effects of high ambient temperature on lipid metabolism in finishing pigs. Journal of Integrative Agriculture. 15 (2): 391-396. ISSN 2095-3119. https://doi.org/10.1016/S2095-3119(15)61061-9

XU Q, Liu J, Wang Z, Guo X, Zhou G, Liu Y, Huang Q, Su L. 2015. Heat stress-induced disruption of endothelial barrier function is via PAR1 signaling and suppressed by Xuebijing injection. PLoS ONE. 10(2): e0118057. ISSN: 1932-6203.

https://doi.org/10.1371/journal.pone.0118057

YU J, Liu F, Yin P, Zhao H, Luan W, Hou X, Zhong Y, Jia D, Zan J, Ma W, Shu B, Xu J. 2013. Involvement of oxidative stress and mitogen-activated protein kinase signaling pathways in heat stress-induced injury in the rat small intestine. Stress. 16(1): 99-113. ISSN: 1607-8888. https://doi.org/10.3109/10253890.2012.680526

ZHANG M, Jiang M, Bi Y, Zhu H, Shou Z, Sha J. 2012. Autophagy and apoptosis act as partners to induce germ cell death after heat stress in mice. PLoS ONE. 7(7): e41412. ISSN: 1932-6203. https://doi.org/10.1371/journal.pone.0041412

ZHAO L, McMillan RP, Xie G, Giridhar SGLW, Baumgard LH, El-Kadi S, Selsby J, Ross J, Gabler N, Hulver MW, Rhoads RP. 2018. Heat stress decreases metabolic flexibility in skeletal muscle of growing pigs. American Journal of Physiology-Regulatory. Integrative and Comparative Physiology. 315(6): R1096-R1106. ISSN 1522-1490. http://doi.org/10.1152/ajpregu.00404.2017

Publicado

2022-12-28

Número

Sección

Revisiones de Literatura