LOS PERFILES DE PROTEÍNAS DE FASE AGUDA COMO BIOMARCADORES EN MEDICINA DE PERROS Y GATOS PROFILES OF ACUTE PHASE PROTEINS IN MEDICINE AS BIOMARKERS IN DOGS AND CATS

Blanca Cardiel-Hernández, Héctor Gutiérrez-Bañuelos, Luis Díaz-García, Laura Polin-Raygoza, Alejandro Espinoza-Canales, Francisco Gutiérrez-Piña, Carlos Meza-López, Alberto Muro-Reyes

Resumen

Las proteínas de fase aguda (PFA) han sido utilizadas como biomarcadores de inflamación, infecciones o traumas, principalmente en la medicina humana; por lo que, ya se cuenta con investigaciones en el área de la medicina veterinaria. A este respecto, ha habido algunos estudios recientes en los animales domésticos tanto de compañía como de abasto. Los biomarcadores predominantes como indicadores de enfermedad han sido principalmente proteína reactiva C, haptoglobina, suero amiloideo, suero amiloide isoforma A-3 y glucoproteínas. La respuesta de tipo de estos biomarcadores o PFA es diferente por especie; pero, en todos los casos pueden coadyuvar en el diagnóstico de enfermedades, el monitoreo de periodos de convalecencia, y/o como indicadores de bienestar animal.

Acute phase proteins (APF) has been used as biomarkers of inflammation, infection or trauma, particularly in human medicine; therefore, already has research in the area of veterinary medicine. In this topic, there have been some recent studies in both pets and farm animals. The dominant biomarker as an indicator of disease have been mainly protein C-reactive, haptoglobin, amyloid serum, isoform of amyloid serum A-3 and glycoproteins. The response rate of these biomarkers or APF differs by species; but in all cases they can assist in the diagnosis of disease, monitoring periods of convalescence, and/or animal welfare indicators.

 

Palabras clave

Protein C reactive, Haptoglobin, serum amyloid-A, alpha 1-acid glycoprotein.

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Referencias

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