Respuesta reproductiva de cabras Saanen x Alpina al aplicar un reconstituyente metabólico durante la sincronización del estro


Palabras clave:

Aminoácidos, fecundidad, gonadotropinas, progestágenos, prolificidad


Se evaluó la acción de un reconstituyente metabólico como respuesta al estro de cabras Saanen x Alpina. Se utilizaron 36 cabras multíparas y se asignaron aleatoriamente a uno de tres tratamientos: T1 (n= 12): CIDR+eCG con reconstituyente metabólico (REC); T2 (n= 12): CIDR+eCG con solución isotónica (ISO); T3 (n= 12): CIDR+eCG (TEST). Se evaluó que los datos provinieran de una población distribuida normalmente. La respuesta al estro (RE), inicio del estro (IE), retorno al estro (RET), gestación (GEST), parición (PAR) y fertilidad (FER) se analizaron mediante la prueba no paramétrica de Kruskal-Wallis; la duración del estro (DE), fecundidad (FEC) y prolificidad (PROL) mediante un análisis de varianza y se utilizó la prueba de Tukey (α= 0.05) para comparar medias entre tratamientos. El tratamiento con REC redujo (p <0.05) el IE (T1: 20.78 h, T2: 32.54 h, T3: 33.68 h), aumentó la FEC (T1: 1.42, T2: 0.92, T3: 0.92) e incrementó la PROL (T1: 2.1, T2: 1.4, T3: 1.4). El tratamiento con ISO tuvo efecto similar al tratamiento TEST (p >0.05) en las variables de estudio. El reconstituyente metabólico durante la sincronización del estro en cabras Saanen x Alpina reduce el inicio del estro e incrementa la fecundidad y la prolificidad.




ABECIA JA, Forcada F, González-Bulnes A. 2011. Pharmaceutical control of reproduction in sheep and goats. Veterinary Clinics of North America: Food Animal Practice. 27: 67-79. ISSN: 0749-0720.

ABECIA JA, Forcada F, González-Bulnes A. 2012. Hormonal control of reproduction in small ruminants. Animal Reproduction Science. 130(3-4): 173-179. ISSN: 0378-4320.

AGUILAR U, Hernández Cerón J, Domínguez Y, Gutiérrez CG. 2016. Ovulation rate, prolificacy and pregnancy rate in goats treated with oral glycerol. Veterinaria México OA. 1: 1-9. ISSN: 2448-6760.

ALVAREZ-Cardona F, Maki-Díaz G, Franco-Robles E, Cadena-Villegas S, Hernández-Marín A. 2019. L-Arginina, Aspartato y Glutamato, y su relación con la reproducción de ovejas. Revisión. Abanico Veterinario. 9(1):1-13. ISSN: 2448-6132.

BARIOGLIO C, Deza M, Arias M, Varela L, Bonardi C, Villar M. 1997. Evaluación de algunos parámetros reproductivos en cabras criollas. AgriScientia. 14: 37-42. ISSN: 1668-298X.

BUKAR MM, Yusoff R, Haron AW, Dhaliwal GK, Khan MA, Omar MA. 2012. Estrus response and follicular development in Boer does synchronized whit flugestone acetate and PGF2α or their combination whit eCG or FSH. Tropical Animal Health and Production. 2012. 44(7): 1505-1511. ISSN: 1573-7438.

DIGBY SN, Chadwick MA, Blache D. 2011. Salt intake and reproductive function in sheep. Animal. 5(8): 1207-1216. ISSN: 1751-7311.

DUBEUF JP. 2011. The social and environmental challenges faced by goat and small livestock local activities: Present contribution of research-development and stakes for the future. Small Ruminant Research. 98(1-3): 3-8. ISSN: 0921-4488.

DUPONT J, Scaramuzzi RJ, Reverchon M. 2014. The effect of nutrition and metabolic status on the development of follicles, oocytes and embryos in ruminants. Animal. 8(7): 1031-1044. ISSN: 1751-7311.

ESCAREÑO SLM, Wurzinger M, Pastor LF, Salinas H, Sölkner J, Iñiguez L. 2011. La cabra y los sistemas de producción caprina de los pequeños productores de la Comarca Lagunera, en el norte de México. Revista Chapingo Serie Ciencias Forestales y del Ambiente. 17: 235-246. ISSN: 2007-4018.

ESTIENNE MJ, Barb CR, Kesner JS, Kraeling RR, Rampacek GB. 1991. Luteinizing hormone secretion in hypophysial stalk-transected gilts given hydrocortisone acetate and pulsatile gonadotropin-releasing hormone. Domestic Animal Endocrinology. 8(3): 407-414. ISSN: 0739-7240.

FATET A, Pellicer-Rubio MT, Leboeuf B. 2011. Reproductive cycle of goats. Animal Reproduction Science. 124(3-4): 211-219. ISSN: 0378-4320.

FIERRO S, Gil J, Viñoles C, Olivera-Muzante J. 2013. The use of prostaglandins in controlling estrous cycle of the ewe: A review. Theriogenology. 79: 399-408. ISSN: 0093-691X.

FORD MM, Thorburn GD, Caddy DJ, Young IR. 1999. Pulsatile output of prostaglandin F2α does not increase around the time of luteolysis in the pregnant goat. Biology of Reproduction. 61(2): 411-415. ISSN: 1529-7268.

FRAIRE-Cordero S, Pérez Rodríguez P, Pérez-Hernández P, Cortez-Romero C, Gallegos-Sánchez J. 2018. Reproductive response of Pelibuey sheep to the application of recombinant bovine somatotropin and a metabolic restorative preparation. Pesquisa Agropecuária Brasileira. 53(12): 1392-1398. ISSN: 1678-3921.

GHOSH CP, Datta S, Mandal D, Das AK, Roy DC, Roy A, Tudu NK. 2019. Body condition scoring in goat: Impact and significance. Journal of Entomology and Zoology Studies. 7(2): 554-560. ISSN: 2349-6800.

GRAFF KJ, Meintjes M, Han Y, Reggio BC, Denniston RS, Gavin WG, Ziomek C, Godke RA. 2000. Comparing follicle stimulating hormone from two commercial sources for oocyte production from out-of-season dairy goats. Journal of Dairy Science. 83: 484-487.

HALDAR A, Pal P, Datta M, Paul R, Pal SK, Majumdar D, Biswas CK, Pan S. 2014. Prolificacy and its relationship with age, body weight, parity, previous litter size and body linear type traits in meat-type goats. Asian-Australas Journal of Animal Science. 27(5): 628–634. ISSN: 1011-2367.

HASHEMI M, Safdarian M. 2017. Efficiency of different methods of estrus synchronization followed by fixed time artificial insemination in Persian downy does. Animal Reproduction. 14(2): 413-417. ISSN: 1984-3143.

HERNÁNDEZ-Marín JA, Pro-Martínez A, Cortez-Romero C, Pérez-Hernández P, Herrera-Corredor CA, Gallegos-Sánchez J. 2016. Ovulation induction with male effect and a commercial energy tonic in prepubertal Pelibuey ewes. Agrociencia. 50(7): 811-823. ISSN: 1405-3195.

JEONG JK, Choi IS, Moon SH, Lee SC, Kang HG, Jung YH, Park SB, Kim IH. 2018. Effect of two treatment protocols for ketosis on the resolution, postpartum health, milk yield, and reproductive outcomes of dairy cows. Theriogenology. 106: 53-59. ISSN: 0093-691X.

KAJAYSRI J, Thammakarn C. 2012. Estrus synchronization using intravaginal medroxyprogesterone acetate (MAP), MAP plus prostaglandin F2, controlled internal drug release (CIDR) or CIDR plus prostaglandin F2 in Saanen dairy goats in Thailand. Kasetsart Journal (Natural Science). 46: 71-79. ISSN: 00755192.

KHANTHUSAENG V, Navanukraw C, Moonmanee T, Thammasiri J. 2013. Efficiency comparison of first use and re-use synthetic progesterone on estrus synchronization and pregnancy rates after natural breeding and Timed AI in goats. Chiang Mai Veterinary Journal. 11: 31-40. ISSN: 1685-9502.

LUO J, Wang W, Sun S. 2019. Research advances in reproduction for dairy goats. Asian-Australasian Journal of Animal Sciences. 32(8): 1284-1295. ISSN: 1976-5517.

MAHESH B, Brann DW. 2005. Regulatory role of excitatory amino acids in reproduction. Endocrine. 28(3): 271-280. ISSN: 1559-0100.

MAIA ALRS, Brandão FZ, Souza-Fabjana JMG, Balaro MFA, Oliveira MEF, Facó O, Fonseca JF. 2017. Reproductive parameters of dairy goats after receiving two doses of d-cloprostenol at different intervals. Animal Reproduction Science. 181: 16-23. ISSN: 0378-4320.

MARTIN GB, Blache D, Miller DW, Vercoe PE. 2010. Interactions between nutrition and reproduction in the management of the mature male ruminant. Animal. 4(7): 1214-1226. ISSN: 1751-7311.

MARTÍNEZ-Rojero RD, Hernández-Ignacio J, Hernández-Hernández H, Michel-Aceves AC, Valencia-Méndez J. 2006. Inseminación artificial intrauterina en cabras criollas con semen refrigerado. Agrociencia. 40: 71-76. ISSN: 1405-3195.

MENCHACA A, Miller V, Salveraglio V, Rubianes E. 2007. Endocrine, luteal and follicular responses after the use of the short-term protocol to synchronize ovulation in goats. Animal Reproduction Science. 102(1-2): 76-87. ISSN: 0378-4320.

MENCHACA A, Rubianes E. 2007. Pregnancy rate obtained with short-term protocol for timed artificial insemination in goats. Reproduction in Domestic Animals. 42(6): 590-593. ISSN: 1439-0531.

MEZA-Herrera CA, González-Velázquez A, Veliz-Deras FG, Rodríguez-Martínez R, Arellano-Rodríguez G, Serradilla JM, García-Martínez A, Avendaño-Reyes L, Macías-Cruz U. 2014. Short-term glutamate administration positively affects the number of antral follicles and the ovulation rate in cyclic adult goats. Reproductive Biology. 14(4): 298-301. ISSN: 1642-431X.

MEZA-Herrera CA, Hallford DM, Ortiz JA, Cuevas RA, Sanchez JM, Salinas H, Mellado M, Gonzalez-Bulnes A. 2008. Body condition and protein supplementation positively affect periovulatory ovarian activity by non LH-mediated pathways in goats. Animal Reproduction Science. 106 (3-4): 412-420. ISSN: 0378-4320.

MEZA-Herrera CA, Veliz Deras FG, Wurzinger M, López Ariza B, Arellano Rodríguez G, Rodríguez Martínez R. 2010. The kiss-1-kisspeptin-gpr-54 complex: a critical modulator of GnRH neurons during pubertal activation. Journal of Applied Biomedicine. 8(1): 1-9. ISSN: 1214-021X.

MEZA-Herrera CA, Vergara-Hernández HP, Paleta-Ochoa A, Álvarez-Ruíz AR, Veliz-Deras FG, Arellano-Rodriguez G, Rosales-Nieto CA, Macias-Cruz U, Rodríguez-Martínez R, Carrillo E. 2020. Glutamate supply reactivates ovarian function while increases serum insulin and triiodothyronine concentrations in Criollo x Saanen-Alpine yearlings’ goats during the anestrous season. Animals. 10(2): 234. ISSN: 2076-2615.

MONTES-Quiroz GL, Sánchez-Dávila F, Grizelj J, Bernal-Barragán H, Vazquez-Armijo JF, del Bosque-González AS, Luna-Palomera C, González Gómez A, Ledezma-Torres RA. 2018. The reinsertion of controlled internal drug release devices in goats does not increase the pregnancy rate after short oestrus synchronization protocol at the beginning of the breeding season. Journal of Applied Animal Research. 46: 714-719. ISSN: 0974-1844.

NIE HT, Wang Z, Guomin MZ, Wang F. 2018. Amino acids profile within peripheral blood and follicular fluid based on high‐performance liquid chromatography methods may explain differences in folliculogenesis between short‐term under/over‐fed treatments during luteal phase of Hu sheep. Reproduction in Domestical Animals. 54: 72-82. ISSN: 0936-6768.

NOGUEIRA DM, Lopes Júnior ES, Moraes de Peixoto R, Christilis M, Rodrigues Martins S, Oliveira do Mont AP. 2011. Using the same CIDR up to three times for estrus synchronization and artificial insemination in dairy goats. Acta Scientiarum. Animal Sciences. 33 (3): 321-325. ISSN: 1807-8672.

O'BRIEN D, Wildeus S. 2019. Optimizing reproductive performance in the goat herd. Professional Agricultural Workers Journal. 6 (2): 78-87. ISSN: 2328-3742.

OMONTESE B, Rekwot P, Rwuaan J, Nwannenna A. 2014. Comparison of short-term vs. longterm progestin treatments for synchronization of oestrus in Red Sokoto does during the rainy season. Basic & Clinical Pharmacology & Toxicology. 115(1): 1-374. ISSN: 1742-7843.

OMONTESE BO, Rekwot PI, Makun HJ, Ate IU, Rwuaan JS, Kawu MU. 2013. Oestrus induction using fluorogestone acetate sponges and equine chorionic gonadotrophin in red Sokoto goats. South African Journal of Animal Science. 43(1): 68-73. ISSN: 2221-4062.

OMONTESE BO. 2018. Estrus synchronization and artificial insemination in goats (Chapter 7). London, United Kingdom. Kukovics S, (ed). Goat Science, IntechOpen. ISBN 978-1-78923-203-5.

PÉREZ-Clariget R, Garese-Raffo JA, Fleischmann-Techera R, Ganzábal-Planinich A, González-Stagnaro C. 2012. Sincronización de celos en cabras en estación reproductiva: uso de esponjas de medroxiprogesterona o aplicación de prostaglandina después de cinco días de detección de celos. Revista Científica FCV-LUZ. 22(3): 245-251. ISSN: 0798-2259.

PINHEIRO ESP, Rondina D, Galeati G, Freitas VJF, Souza AL, Teixeira DIA, Almeida KC, Gavoni N, Lima IMT. 2012. Estrus and ovarian responses following the administration of different insulin doses following progestagen-cloprostenol treatment in mated does during the dry season. Small Ruminant Research. 105(1-3): 282-285. ISSN: 0921-4488.

REKIK M, Lassoued N, Salem HB, Mahouachi M. 2007. Interactions between nutrition and reproduction in sheep and goats with particular reference to the use of alternative feed sources. In : Priolo A (ed.), Bion di L (ed.), Salem HB (ed.), Morand-Fehr P (ed.). Advanced nutrition and feeding strategies to improve sheep and goat. Zaragoza, España: CIHEAM. Pp. 375-383. (Options Méditerranéennes: Série A. Séminaires Méditerranéens; no. 74). 11. Seminar of the FAO-CIHEAM Sub-Network on Sheep and Goat Nutrition, 2005/09/08-10, Catania (Italy).

RIVAS-Muñoz R, Zúñiga-García S, Arellano-Rodríguez G, Arellano-Rodríguez F, Gaytán-Alemán L, Contreras-Villarreal V. 2021. Efecto de un protocolo de prostaglandina a corto plazo sobre la sincronización y resultados reproductivos en las cabras cíclicas. Abanico Veterinario. 11: 1-10. ISSN: 2448-6132.

RODRIGUES M, Moreira Silva L, Gomes da Silva CM, Araújo AA, Sousa Nunes-Pinheiro DC, Rondina D. 2015. Reproductive and metabolic responses in ewes to dietary protein supplement during mating period in dry season of northeast Brazil. Ciencia Animal Brasileira.16(1): 24-36. ISSN: 1809-6891.

RUÍZ R, Fernández JL, de la Vega AC, Rabasa AE. 2002. Evaluación de diferentes tratamientos hormonales para la sincronización del estro en cabras criollas serranas durante el verano. Zootecnia Tropical. 20(4): 473-482. ISSN: 0798-7269.

SAGARPA (Secretaría de Agricultura, Ganadería, Pesca y Alimentación). 1995. Especificaciones y características zoosanitarias para el transporte de animales, sus productos y subproductos, productos químicos, farmacéuticos, biológicos y alimenticios para uso en animales o consumo por éstos. Norma Oficial Mexicana 024-ZOO-1995, México: Diario Oficial de la Federación, pp. 41-46.

SAGARPA (Secretaría de Agricultura, Ganadería, Pesca y Alimentación). 1995. Trato humanitario en la movilización de animales. Norma Oficial Mexicana 051-ZOO-1995, México: Diario Oficial de la Federación, pp. 42-67.

SALLEH SM, Hassan Basri AM, Yaakub H. 2021. Study of sexual behaviours with different types of estrus synchronization protocols in Boer goats. Animal Reproduction. 18(3): 1-10. ISSN: 1984-3143.

SAS Institute. 2012. Statistical Analysis Software SAS/STAT®. version 9.4, Cary, N.C., USA: SAS Institute Inc., ISBN: 978-1-60764-599-3.

SCARAMUZZI RJ, Brown HM, Dupont J. 2010. Nutritional and metabolic mechanisms in the ovary and their role in mediating the effects of diet on folliculogenesis: A perspective. Reproduction in Domestic Animal. 45(S3): 32-41. ISSN: 1439-0531.

SCHNEIDER JE, Klingerman CM, Abdulhay A. 2012. Sense and nonsense in metabolic control of reproduction. Frontiers in Endocrinology. 3(26): 1-21. ISSN: 1664-2392.

SHAPIRO SS, Wilk MB. 1965. An analysis of variance test for normality. Biometrika. 52(3/4): 591-611.

SPALLHOLZ JE. 1994. On the nature of selenium toxicity and carcinostatic activity. Free Radical Biology and Medicine. 17: 45-64. ISSN: 0891-5849.

SWELUM AAA, Alowaimer AN, Abouheif MA. 2015. Use of fluorogestone acetate sponges or controlled internal drug release for estrus synchronization in ewes: effects of hormonal profiles and reproductive performance. Theriogenology. 84: 498-503. ISSN: 0093-691X.

URIBE-Velásquez LF, Gutiérrez Toro C, Carreño Ortiz EE, Izquierdo Jiménez JH, Lenz Souza MI, Ángel Botero S. 2011. Reutilización del dispositivo de progesterona (CIDR) asociado con protocolos de corta duración en cabras. Veterinária e Zootecnia. 5(1): 39-46. ISSN: 0102-571.

URIBE-Velásquez LF, Oba E, Souza MIL. 2008. Población folicular y concentraciones plasmáticas de progesterona en ovejas sometidas a diferentes protocolos de sincronización. Archivos de Medicina Veterinaria. 40: 83-88. ISSN: 0301-732X.

VÁZQUEZ-Armijo JF, Rojo R, López D, Tinoco JL, González A, Pescador N, Domínguez-Vara IA. 2011. Trace elements in sheep and goats reproduction: A review. Tropical and Subtropical Agroecosystems. 14: 1–13. ISSN: 1870-0462.

WALKDEN-Brown SW, Restall BJ, Norton BW, Scaramuzzi RJ, Martin GB. 1994. Effect of nutrition on seasonal patterns of LH, FSH and testosterone concentration, testicular mass, sebaceous gland volume and odour in Australian cashmere goats. Journal Reproduction and Fertility. 102: 351–360. ISSN: 1741-7899.

WU G. 2010. Functional amino acids in growth, reproduction, and health. Advances in Nutrition. 1(1): 31-37. ISSN: 2156-5376.

WU G. 2014. Dietary requirements of synthesizable amino acids by animals: a paradigm shift in protein nutrition. Journal of Animal Science and Biotechnology. 5(34): 1-12. ISSN: 2049-1891.

YING S, Wang Z, Wang C, Nie H, He D, Jia R, Wu Y, Wan Y, Zhou Z, Yan Y, Zhang Y, Wang F. 2011. Effect of different levels of short‐term feed intake on folliculogenesis and follicular fluid and blood plasma concentrations of lactate dehydrogenase, glucose, and hormones in Hu sheep during the luteal phase. Reproduction. 142: 699-710. ISSN: 1470-1626.





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